Plaid Cymru are unchanged on 13%, but UKIP's vote has collapsed from 13% to 6% since January.
Wales has been a Labour stronghold for decades.
More than 1,000 pollsters were interviewed and yet only 30 per cent indicated their intention to vote Labour, a decrease of three per cent since the start of 2017.
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Ms Wood will say her party plans to capitalise on Labour's poor opinion poll ratings and divisions over its leader Jeremy Corbyn.
The Conservatives are set to win the most Welsh House of Commons seats for the first time in 100 years, according to a YouGov poll published on Monday 24 April.
"I can find no precedent in any poll this century either for the Conservatives to be on 40 percent in Wales or for them to have a ten percentage point lead over Labour in general election voting intentions", said Scully.
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The following seats would go from Labour to Tory: Bridgend, Wrexham, Clwyd South, Delyn, Alyn & Deeside, Newport West, Ynys Mon, Newport East, Cardiff West, Cardiff South & Penarth.
That would see 10 seats switching from Labour to Conservative, compared with the last national election in 2015.
Mrs May is also expected to warn Welsh voters that a Labour commitment to borrow £500 billion to fund a grand spending spree after Carwyn Jones, the Welsh Labour leader and First Minister of Wales, justified it by saying "there's never been a better time to borrow". Nearly two-thirds of respondents who voted UKIP in the 2015 general election now say that they intend to support the Tories.
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But few Welsh Labour MPs backed him, many fearing the Tory surge of the 2015 general election - and the fact Wales voted for "Leave" in the 2016 European Union referendum - was an ominous warning of the dangers posed by votes lost to UKIP.